Boekel Scientific

Congrats to Monette and team at HIV-1 RNA Trafficking Laboratory, Lady Davis Institute at the Jewish General Hospital in Montréal for their published work in Cell Reports Journal. Their work found that 'NC-mediated, Zn2+-coordinated phase separation is conserved among diverse retrovirus subfamilies, illustrating that this exquisitely evolved Zn2+-dependent feature of virus replication represents a critical target for pan-antiretroviral therapies.' Copyright 2020 The Autho...r(s). Published by Elsevier Inc. All rights reserved. The team utilized the Hybridization Oven Boekel Scientific Model 24100. http://ow.ly/f2Rw50D5TUH

Congrats to Liu & team at Department of Pathology, Yale University School of Medicine for their work published in the Clinical Cancer Research Journal. The team utilized Boekel Scientific's Slide Moat for their research. Below is a snippet of their findings. "Here, we examine the expression of PD-L1 to determine which cell type carries the predictive value of the test. PD-L1 was significantly higher in macrophages in both tumor and stromal compartment compared with other immu...ne cells. In nearly 500 non-small cell lung cancer (NSCLC) cases, the predominant immune cell type that expresses PD-L1 is CD68+ macrophages. The level of PD-L1 in macrophages is significantly associated with the level of PD-L1 in tumor cells and infiltration by CD8+ T cells, suggesting a connection between high PD-L1 and "hot" tumors. In anti-PD-1 axis therapy-treated patients, high levels of PD-L1 expression in macrophages are associated with longer OS and may be responsible for the predictive effect of the marker." 2019 American Association for Cancer Research. http://ow.ly/UOTh50D2K05

Congrats to Wienert, Wyman, Yeh, Conklin, and Corn at the Innovative Genomics Institute, University of California, Berkeley, for being published in the Journal of Natural Protocols for their work in DISCOVER-seq (discovery of in situ Cas off-targets and verification by sequencing). The team describes a detailed experimental protocol and analysis pipeline with which to perform DISCOVER-seq. The principle of this method is to track the precise recruitment of MRE11 to DSBs by c...hromatin immunoprecipitation followed by next-generation sequencing. A customized open-source bioinformatics pipeline, BLENDER (blunt end finder), then identifies off-target sequences genome wide. DISCOVER-seq is capable of finding and measuring off-targets in primary cells and in situ. The Cal Berkley team utilized Boekel's Hybridization Oven. Journal Link: https://www.nature.com/articles/s41596-020-0309-5 Product Link: http://ow.ly/hWWd50D0YUd

Boekel Scientific was awarded AABB Standards-Compliant Product Evaluation (SCoPE) Programs. SCoPE is an initiative to determine vendor product compliance and evaluates blood banking equipment, and supplies for consistency and performance.

Citation Alert Study reveals DNA 6mA as a regulatory mark in mammalian mtDNA Congratulations Z. Hao & team at the University of Chicago's. The experiment used a Boekel Orbiton Rotator & published in Mol. Cell Volume: 78 https://bit.ly/38FhxHf